Product name:NPI-0052
Description:NPI-0052 is a novel proteasome inhibitor that was isolated from Salinispora tropica, a newly discovered marine actinomycete.NPI-0052 is a bicyclic b-lactone g-lactam and therefore significantly differs structurally from other proteasome inhibitors in development that are peptide mimetics.The structural differences apparently are important for the significant differences in proteasome inhibition, toxicology and efficacy profiles between these two classes of inhibitors. NPI-0052 offers significant possibilities in the treatment of many cancers.