Product name:Bryostatin 1
CAS:83314-01-6
Molecular Formula:C47H68O17
Molecular Weight:905.03g/mol
Description:Bryostatin 1 is a macrolactone isolated from the marine bryozoan, Bugula neritina, that modulates protein kinase C (PKC) activity. Bryostatins compete with the phorbol esters and diacylglycerols for binding to the cysteine-rich domains CRD1 and CRD2 of PKC.Bryostain 1 induces an initial rapid activation and autophosphorylation of PKC that results in the translocation of the PKC enzyme to the membrane.PKC is subsequently down-regulated by ubiquitination and proteolysis.