PD0332991

by:Acridine Raw Material,Pharmaceutical Chemicals,Fine Chemicals,Chemicals
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Product name:PD0332991

CAS
:571190-30-2

Molecular Formula:C24H29N7O2

Description
:PD-0332991 selectively inhibits cyclin-dependent kinases (particularly Cdk4/cyclin D1 kinase), which may inhibit retinoblastoma (Rb) protein phosphorylation; inhibition of Rb phosphorylation prevents Rb-positive tumor cells from entering the S phase of the cell cycle (arrest in the G1 phase), resulting in suppression of DNA replication and decreased tumor cell proliferation.

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