AZD1152

by:Acridine Raw Material,Pharmaceutical Chemicals,Fine Chemicals,Chemicals
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Product name:AZD1152

CAS
:722543-31-9

Molecular Formula:C26H31FN7O6P

Description
:AZD1152, an Aurora kinase inhibitor with selectivity for Aurora B kinase, can enhance the effect of ionizing radiation (IR).Time-lapse videomicroscopy confirmed that cell death induced by AZD1152 + IR was preceded by multinucleation and the formation of micronuclei, which both are hallmarks of mitotic catastrophe. Caspase inhibition or removal of the pro-apoptotic protein Bax did not ameliorate the long-term cell survival of AZD1152-treated cancer cells.

Pre:BI 2536Next:PD0332991
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